Your PS3 should not require much general maintenance, though we would advise that the system be used in a well-ventilated area. Because the PS3 has several fans inside it, it is also advisable to try an keep the PS3 relatively dust free. Wiping dust off the surface and sides of the PS3 every few months with a slightly damp cloth can help.
If you decide to stand your PS3 on its side, be careful not to stand it on the side which has a vent. If you are unsure, the disc tray should be on the upper half.