Inhibition
of prostaglandin synthetase by limonoids (and/or polysaccharides)
reduces perceived pain.
Both as topical applications and as oral medicines, Neem
provides a low cost pain reliever and fever-reducing remedy.
Neem leaf and bark extracts have been shown to be a more
potent inhibitor of prostaglandin synthetase than acetylsalicylic
acid (aspirin) and pethidine hydrochloride. (Okpako, 1977); (Pillai,
1978b); (Tandan, et al, 1990).
In some cases neem was effective at reducing pain for a significantly
longer period than standard agents. Neem also reduces the activity
of the central nervous system, which also reduces perceived pain
(Debelmas, 1976).
According to a study led by N. Khanna, neem produces an analgesic
effect upon the central and peripheral neural pathways. He also
feels that both opioid and non-opioid receptors can be affected
by neem.(Khanna et al, 1995)
Nimbin:
anti-inflammatory, anti-pyretic,
anti-histamine, anti-fungal
Nimbidin: anti-bacterial, anti-ulcer, analgesic,
anti-arrhythmic, anti-fungal
Ninbidol: anti-tubercular, anti-protozoan,
anti-pyretic
Gedunin: vasodilator, anti-malarial, anti-fungal
Sodium nimbinate: diuretic, spermicide,
anti-arthritic
Quercetin: anti-protozoal
Salannin: insect repellent
Azadirachtin: insect repellent, anti-feedant,
anti-hormonal
This is a PDF file to read this you will require. You can download
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Indian Journal of Pharmacology
2000; 32: 372-374 - ANTINOCICEPTIVE ACTIVITY OF AZADIRACHTA INDICA
(NEEM) IN RATS....READ
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