On September 3rd,1888, St. Patrick's De La Salle opened as a three teacher school at Upper Patrick Street. Initially, there were 107 boys on the roll and Brother Edmund O'Donnell, John Sharkett and Mercier Cullen were the three teachers in charge. That school was used up to 1953, when the Brothers moved to the present location in Coote's Lane. It remained as a three teacher school until the 1960s when both Sheestown and Folkstown schools were closed, with the boys transferring to St. Patrick's De La Salle. This marked the first appearance of lay staff in St. Patrick's De La Salle.

1976 marked the next major development in St. Patrick's, with the completion of an eight classroom extension and a General Purpose Hall. The teaching staff had now increased to ten.
December 1985 saw the completion of the latest extension to the school. This comprises of six new classrooms,replacement General Purpose Hall and extensive renovations to the existing building. A new sportsfield adjacent to the school was also acquired and is presently in use.
September 1st 1986 sadly saw the departure of the De La Salle Order and the De La Salle Brothers Kieran Creedon(Superior), Michael Denby and Cyril Collins from the parish.This marked the end of the De La Salle Order's unbroken association with education for 98 years. The present school is a fitting monument to the contribution that the De La Salle Brothers have made to St. Patrick's Parish since 1888.